An immense unmet
medical need: Aortic Stenosis

A non-invasive therapy to treat Aortic Stenosis

Quality of life improvement


Cardiawave has developed a unique non-invasive ultrasound therapy for the treatment of calcific aortic stenosis.


Our mission is to improve the quality of patient care by offering medical devices for non-invasive therapies.


Discover our job offers!



Aortic stenosis is one of the most common and serious valve disease problems. It is a life-threatening disease caused by the narrowing of the opening of the aortic valve.

  • most frequent cardiovascular disease in developed countries (1) (2).

  • number of elderly patients with severe symptomatic aortic stenosis in North America in 2025 and 1.4 million in 2050 ; 1.3 millon in Europe in 2025 and 2.1 million in 2050 (3).

  • health spending to treat symptomatic aortic valve disease in the United States of America (4).

  • of severe symptomatic aortic stenosis patients remain untreated in the United States of America (5).

1 Durko AP, et al. Annual number of candidates for transcatheter aortic valve implantation per country: current estimates and future projections. European Heart Journal. July 01, 2018; 39(28):2635-2642. (DOI: 10.1093/eurheartj/ehy107)
2 Lindman B, et al. Calcific Aortic Stenosis. Nature Reviews Disease Primers 2, Article number: 16006. March 03, 2016. (DOI: 10.1038/nrdp.2016.6)
3 Osnabrugge R., et al. Aortic Stenosis in the Elderly: Disease Prevalence and Number of Candidates for Transcatheter Aortic Valve Replacement: A Meta-Analysis and Modeling Study. Journal of American College of Cardiology, Volume 62, Issue 11, Pages 1013-1014. September 2013. (DOI: 10.1016/j.jacc.2013.05.015)
4 Moore M, et al. The direct health-care burden of valvular heart disease: evidence from US national survey data. Clinicoeconomics and Outcomes Research. October 18, 2016; 8:613-627 (DOI: 10.2147/CEOR.S112691).
5 Wood S. Vast Numbers of Severe Symptomatic AS Patients Untreated? A Plea and Some Pushback. TCTMD. June 14, 2019.


To treat Aortic Stenosis, Cardiawave has developed a real-time image-guided non-invasive ultrasound therapy using a cutting-edge ultrasound technology.

Non-Invasive Ultrasound Therapy (NIUT) consists in repairing the aortic valve, not replacing it. No surgery is required. Truly non-invasive.


This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 829492.


This project has received funding from the Innov’Up of the Ile-de-France region program under grant agreement No DOS0133065/00.


This project is supported by the French Government, managed by the National Research Agency (ANR) under the program “Investissements d’avenir” with the reference ANR-16-RHUS-0003.